I have chronic pain due to neuropathy. I am a pain management patient, and was looking for something natural to help with breakthrough pain. It doesn't replace my pain medication, but it does relieve the edginess I get from the pain and extends the amount of time I can go between doses, and I don't feel the need to take ibuprofen. It's also helped a lot with my migraines and helps a lot with breakthrough pain, as well as aches and pains I get from aging. These were the first patches I tried, and I now regularly use the Calm patches as well. I love the fact that they're all natural and that they last about 48 hours. Much better value than other patches I've tried that are way more expensive and only last about 12 hours.